Vaginal drug delivery approaches for localized management of cervical cancer

• Published in: Advanced drug delivery reviews Vol. 174; pp. 114 - 126
• Main Authors: Wang, Xue, Liu, Shi, Guan, Yuyao, Ding, Jun, Ma, Chong, Xie, Zhigang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-07-2021
• Subjects: Administration, Intravaginal; Animals; Cervical cancer; Cervical intraepithelial neoplasia; Cervical Intraepithelial Neoplasia - drug therapy; Delayed-Action Preparations; Drug Delivery Systems; Female; Genetic Therapy - methods; Humans; Localized treatment; Nanostructures; Nanotechnology; Phototherapy - methods; Uterine Cervical Neoplasms - drug therapy; Vaginal drug delivery; Localized treatment; Vaginal drug delivery; Cervical intraepithelial neoplasia; Cervical cancer
• ISSN: 0169-409X; 1872-8294
• DOI: 10.1016/j.addr.2021.04.009

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Cervical cancer or cervical intraepithelial neoplasia (CIN) remain a major public health problem among women globally. Traditional methods such as surgery are often associated with possible complications which may impact future pregnancies and childbirth especially for young female patients. Vagina with a high contact surface is a suitable route for the local and systemic delivery of drugs but its abundant mucus in continuous exchange presents a barrier for the popularization of conventional vaginal formulations including suppositories, gel, patch, creams and so on. So the development of new pharmaceutical forms based on nanotechnology became appealing owing to its several advantages such as mucosa penetration, bioadhesion, controlled drug release, and decreased adverse effects. This review provided an overview of the development of topical treatment of cervical cancer or CIN through vaginal drug delivery ranging from conventional vaginal formulations to new nanocarriers to the newly developed phototherapy and gene therapy, analyzing the problems faced by current methods used, and advising the developing trend in future. The methods of establishing preclinical animal model are also discussed.