Induction of Several Adaptive Enzymes by Actinomycin D
Although actinomycin D has been used to prevent protein synthesis in experiments of several hours' duration, its effects on the synthesis of adaptive enzymes which are induced over a period of several days have received less attention. Treatment of young rats with doses of actinomycin D, which...
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| Published in: | Science (American Association for the Advancement of Science) Vol. 146; no. 3644; pp. 661 - 663 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
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American Association for the Advancement of Science
30-10-1964
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| Abstract | Although actinomycin D has been used to prevent protein synthesis in experiments of several hours' duration, its effects on the synthesis of adaptive enzymes which are induced over a period of several days have received less attention. Treatment of young rats with doses of actinomycin D, which permitted survival for a period of 5 days, resulted in marked increases in the activities of four hepatic enzymes known to be induced by cortisol: alanine transaminase, tyrosine transaminase, serine dehydrase, and tryptophan pyrrolase. Actinomycin D also induced responses of two of these enzymes in adrenalectomized rats. |
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| AbstractList | Although actinomycin D has been used to prevent protein synthesis in experiments of several hours' duration, its effects on the synthesis of adaptive enzymes which are induced over a period of several days have received less attention. Treatment of young rats with doses of actinomycin D, which permitted survival for a period of 5 days, resulted in marked increases in the activities of four hepatic enzymes known to be induced by cortisol: alanine transaminase, tyrosine transaminase, serine dehydrase, and tryptophan pyrrolase. Actinomycin D also induced responses of two of these enzymes in adrenalectomized rats. |
| Author | Nichol, Charles A. Rosen, Fred Milholland, Richard J. Raina, Prem Nath |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/14191708$$D View this record in MEDLINE/PubMed |
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| Keywords | LIVER ENZYMOLOGY METABOLISM PHARMACOLOGY EXPERIMENTAL LAB STUDY RATS ALANINE AMINOTRANSFERASE HYDRO-LYASES ACTINOMYCIN HYDROCORTISONE ADRENALECTOMY AMINOTRANSFERASES |
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| SubjectTerms | Actinomycin Adrenalectomy Alanine Transaminase Antibiotics Antibody formation Dactinomycin Dosage Enzymes Gene induction Hydro-Lyases Hydrocortisone Liver Liver - enzymology Liver cells Metabolism Old Medline Pharmacology Protein synthesis Rats RNA Serine Transaminases |
| Title | Induction of Several Adaptive Enzymes by Actinomycin D |
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