Immunoregulatory And Proinflammatory Cytokine Production In Visceral And Cutaneous Leishmaniasis

• Published in: The Journal of infectious diseases Vol. 170; no. 4; pp. 1037 - 1040
• Main Authors: Raziuddin, Syed, Abdalla, Rashid E., EI-Awad, EI-Hag, AI-Janadi, Mansour
• Format: Journal Article
• Language: English
• Published: United States The University of Chicago Press 01-10-1994; University of Chicago Press
• Subjects: Blood; Cells, Cultured; Child; Child, Preschool; Concise Communication; Cutaneous leishmaniasis; Cytokines; Cytokines - biosynthesis; Female; Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis; Humans; Interleukins - biosynthesis; Leishmaniasis; Leishmaniasis, Cutaneous - immunology; Leishmaniasis, Visceral - immunology; Lipopolysaccharides; Lipopolysaccharides - pharmacology; Lymphocyte Activation; Lymphocytes - drug effects; Lymphocytes - immunology; Male; Neutrophils; Parasitic diseases; Pathogenesis; Reference Values; T lymphocytes; Tumor Necrosis Factor-alpha - biosynthesis; Visceral leishmaniasis
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/170.4.1037

Visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL) are the major parasitic diseases in which the immune system is implicated in pathogenesis. The in vitro production of interleukin (IL)-2, IL-4, IL-6, IL-8, tumor necrosis factor-a (TNFa), and granulocyte-macrophage colonystimulating factor (GM-CSF), spontaneously and in response to stimulation of peripheral blood mononuclear cells with anti-CD3, phytohemagglutinin, and lipopolysaccharide, was investigated to determine their importance in VL and CL. Highly enhanced production of IL-4, IL-6, IL-8, and TNFa was seen in VL. However, enhanced production ofIL-4 and TNFa but almost normal production of IL-6 and IL-8 was seen in CL. The highly increased IL-4 production was the most characteristic and common feature of both VL and CL. Of interest, highly deficient GM-CSF production may be implicated in abnormalities in synthesis of hematopoietic lineage of cells in these diseases.