Lactoferrin as a regenerative agent: The old-new panacea?

• Published in: Pharmacological research Vol. 167; p. 105564
• Main Authors: Antoshin, Artem A., Shpichka, Anastasia I., Huang, Guilin, Chen, Kuo, Lu, Pengwei, Svistunov, Andrey A., Lychagin, Alexey V., Lipina, Marina M., Sinelnikov, Mikhail Y., Reshetov, Igor V., Timashev, Peter S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01-05-2021
• Subjects: Animals; Anti-Infective Agents - pharmacology; Anti-Infective Agents - therapeutic use; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Antioxidants - pharmacology; Antioxidants - therapeutic use; Cell therapy; Humans; Lactoferricin; Lactoferrin; Lactoferrin - pharmacology; Lactoferrin - therapeutic use; Lactotransferrin; Regeneration; Regeneration - drug effects; Regenerative Medicine; Signaling; Stem cells; Stem Cells - drug effects; Tissue engineering; Lactoferricin; Signaling; Regeneration; Lactoferrin; Lactotransferrin; Cell therapy; Tissue engineering; Regenerative medicine; Stem cells
• ISSN: 1043-6618; 1096-1186
• DOI: 10.1016/j.phrs.2021.105564

Lactoferrin (Lf) possesses various biological properties and therapeutic potentials being a perspective anti-inflammatory, antibacterial, antiviral, antioxidant, antitumor, and immunomodulatory agent. A significant body of literature has also demonstrated that Lf modulates regenerative processes in different anatomical structures, such as bone, cartilage, skin, mucosa, cornea, tendon, vasculature, and adipose tissue. Hence, this review collected and analyzed the data on the regenerative effects of Lf, as well as paid specific attention to their molecular basis. Furthermore, tissue and condition-specific activities of different Lf types as well as problems of their delivery to the targeted organs were discussed. The authors strongly hope that this review will stimulate researchers to focus on the highlighted topics thus accelerating the progress of Lf’s wider clinical application.
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