SOX9 dependent FOXA1 expression promotes tumorigenesis in lung carcinoma

• Published in: Biochemical and biophysical research communications Vol. 516; no. 1; pp. 236 - 244
• Main Authors: Wang, Xiuyu, Yin, Yanhua, Du, Ran
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13-08-2019
• Subjects: Expression; FOXA1; Lung carcinoma; SOX9; Tumorigenesis; FOXA1; Tumorigenesis; Lung carcinoma; SOX9; Expression
• ISSN: 0006-291X; 1090-2104
• DOI: 10.1016/j.bbrc.2019.05.169

The malignant proliferation is one of the major characteristic for tumor cells, however the mechanism of lung cancer cells uncontrollable proliferation is still confusing. This study investigated the mechanism of up-regulated FOXA1 in lung cancer and its tumorigenic function in lung cancer. FOXA1 showed an increasing expression pattern with the pathological progression in lung cancer, and SOX9 expression pattern is positively correlated with FOXA1. Furthermore, combined up-regulated FOXA1 and SOX9 usually resulted in a poor survival prognosis of patients with lung cancer. In addition, SOX9 was identified as a transcription factor of FOXA1 in lung cancer and involved in affecting the expression of FOXA1 targeted genes—Bcl2, CDKN1B, RPRM and NKX2. What's more, SOX9 can rescue the declining tumorigenic ability of lung cancer cells caused by FOXA1 silenced. This study indicates that SOX9 dependent FOXA1 expression promotes tumorigenic ability of lung cancer cells.
•FOXA1 and SOX9 are up-regulated in lung carcinoma.•SOX9 is a transcriptional regulator of FOXA1.•SOX9 dependent FOXA1 expression promotes tumorigenesis in lung carcinoma.