Synthesis and anti-inflammatory activity of some novel 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives

• Published in: Bioorganic & medicinal chemistry letters Vol. 21; no. 14; pp. 4138 - 4140
• Main Authors: Nagarapu, Lingaiah, Mateti, Jhansi, Gaikwad, Hanmant K, Bantu, Rajashaker, Sheeba Rani, M, Prameela Subhashini, N.J
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 15-07-2011; Elsevier
• Subjects: Amides - chemical synthesis; Amides - chemistry; Amides - therapeutic use; Animals; anti-inflammatory activity; anti-inflammatory agents; Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Carrageenan - toxicity; chemistry; edema; Edema - chemically induced; Edema - drug therapy; Medical sciences; Pharmacology. Drug treatments; Pyrazoles - chemistry; Rats; Pyrazole carboxamide derivative; Five membered ring; Rat; Nitrogen heterocycle; Rodentia; Benzene derivatives; Celecoxib; Non steroidal antiinflammatory agent; Nonsterodial anti-inflammatory drugs; Vertebrata; Mammalia; Structure activity relation; Animal; Six membered ring; Ibuprofen; Carboxamide; Piperazine derivatives; Chemical synthesis
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2011.05.105

A new series of 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives were synthesized and investigated their anti-inflammatory activities using carrageenan-induced rat paw edema model in vivo. All the synthesized compounds were found to be potent anti-inflammatory agents.