Methicillin-resistant Staphylococcus aureus infections: A review of the currently available treatment options

•Treatment options for MRSA among different types of infections are described.•Vancomycin remains a possible, but patient-tailored, option.•New lipoglycopeptides and third-generation cephalosporins have good potency and efficacy.•Tedizolid is an attractive agent for use both in hospital and communit...

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Published in:Journal of global antimicrobial resistance. Vol. 7; pp. 178 - 186
Main Authors: Purrello, S.M., Garau, J., Giamarellos, E., Mazzei, T., Pea, F., Soriano, A., Stefani, S.
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ltd 01-12-2016
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Summary:•Treatment options for MRSA among different types of infections are described.•Vancomycin remains a possible, but patient-tailored, option.•New lipoglycopeptides and third-generation cephalosporins have good potency and efficacy.•Tedizolid is an attractive agent for use both in hospital and community settings.•More data from clinical practice are needed to assign specific roles to each antibiotic. This review is the result of discussions that took place at the 5th MRSA Working Group Consensus Meeting and explores the possible treatment options available for different types of infections due to methicillin-resistant Staphylococcus aureus (MRSA), focusing on those antibiotics that could represent a valid alternative to vancomycin. In fact, whilst vancomycin remains a viable option, its therapy is moving towards individualised dosing. Other drugs, such as the new lipoglycopeptides (oritavancin, dalbavancin and telavancin) and fifth-generation cephalosporins (ceftaroline and ceftobiprole), are showing good in vitro potency and in vivo efficacy, especially for patients infected with micro-organisms with higher vancomycin minimum inhibitory concentrations (MICs). Tedizolid is an attractive agent for use both in hospital and community settings, but the post-marketing data will better clarify its potential. Daptomycin and linezolid have shown non-inferiority to vancomycin in the treatment of MRSA bacteraemia and non-inferiority/superiority to vancomycin in the treatment of hospital-acquired pneumonia. Thus, several options are available, but more data from clinical practice, especially for invasive infections, are needed to assign specific roles to each antibiotic and to definitely include them in the new antibacterial armamentarium.
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ISSN:2213-7165
2213-7173
DOI:10.1016/j.jgar.2016.07.010