Papilloma of the Fallopian Tube: A Rare Gynecologic Neoplasm Harboring a BRAF (c.1799T>A) Mutation (V600E)

• Published in: International journal of gynecological pathology Vol. 38; no. 5; pp. 459 - 463
• Main Authors: Wohlschlaeger, Jeremias, Davidson, Ben, Worm, Karl, Feist, Henning, Peters, Jochen, Hager, Thomas, Schmid, Kurt W, Ostertag, Horst
• Format: Journal Article
• Language: English
• Published: United States International Society of Gynecological Pathologists 01-09-2019
• Subjects: Fallopian Tube Neoplasms - genetics; Fallopian Tube Neoplasms - pathology; Female; Humans; Middle Aged; Mutation; Papilloma - genetics; Papilloma - pathology; Proto-Oncogene Proteins B-raf - genetics
• ISSN: 0277-1691; 1538-7151
• DOI: 10.1097/PGP.0000000000000526

Papillomas of the fallopian tube are exceedingly rare benign tumors, and only very few cases have been reported in the literature. Clinically, they may present as a mass lesion or occur without symptoms. Histomorphologically, they are papillary tumors covered by nonatypical epithelium with occasional ciliated or goblet cells growing in the lumen, and they are most frequently located in the infundibular region of the fallopian tube. They require a number of differential diagnostic evaluations and can be mistaken for either other benign tumors or malignant neoplasms. Because of their rare occurrence, molecular data about this entity have been lacking so far. Herein, a case of a papilloma with a BRAF (c.1799T>A) mutation (V600E) in a 45-yr-old woman with tumor-like dilation of the fallopian tube is presented.