Dry Eye Assessment in Patients With Vitamin D Deficiency

• Published in: Eye & contact lens Vol. 44 Suppl 1; no. 1; pp. S62 - S65
• Main Authors: Demirci, Goktug, Karaman Erdur, Sevil, Ozsutcu, Mustafa, Eliacik, Mustafa, Olmuscelik, Oktay, Aydin, Rukiye, Kocabora, Mehmet Selim
• Format: Journal Article
• Language: English
• Published: United States Contact Lens Association of Ophthalmologists, Inc 01-09-2018
• Subjects: Adult; Case-Control Studies; Cross-Sectional Studies; Dry Eye Syndromes - diagnosis; Dry Eye Syndromes - etiology; Dry Eye Syndromes - metabolism; Female; Humans; Male; Middle Aged; Tears - metabolism; Vitamin D Deficiency - complications; Vitamin D Deficiency - metabolism
• ISSN: 1542-2321; 1542-233X
• DOI: 10.1097/ICL.0000000000000325

OBJECTIVES:The aim of this study was to evaluate tear film function in patients with vitamin D deficiency.
METHODS:In a single center, 60 eyes of 30 patients with vitamin D deficiency (group 1), and 60 eyes of 30 healthy individuals (group 2) were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, tear break-up time (TBUT), scoring of ocular surface fluorescein staining using a modified Oxford scale, and tear osmolarity.
RESULTS:Tear osmolarity values, OSDI, and Oxford scale scores were significantly higher in group 1 (309±9 mOsm/L, 35.78±21.44 and 1.3±0.9, respectively) compared with group 2 (295±10 mOsm/L, 18.69±17.21 and 0.4±0.8, respectively) (P<0.001 for all). Schirmer I test and TBUT results in group 1 (8.5±3.7 mm and 8.7±0.6 sec, respectively) were significantly lower compared with group 2 (16.6±2.4 and 18.1±0.5, respectively) (P<0.001 for all).
CONCLUSIONS:This study demonstrates that vitamin D deficiency is associated with tear hyperosmolarity and tear film dysfunction. Patients with vitamin D deficiency may be prone to dry eye.