Addition of Antibacterial Agents to MMA-TBB Dentin Bonding Systems Influence on Tensile Bond Strength and Antibacterial Effect

• Published in: Dental Materials Journal Vol. 19; no. 1; pp. 65 - 74
• Main Authors: KUDOU, Yoshiyuki, OBARA, Kenichi, KAWASHIMA, Toshihiro, KUBOTA, Minoru, ABE, Satoshi, ENDO, Tatsuo, KOMATSU, Masashi, OKUDA, Reiichi
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society for Dental Materials and Devices 2000
• Subjects: 4-META/MMA-TBB resin; Acrylic Resins - chemistry; Actinomyces - drug effects; Actinomyces viscosus - drug effects; Analysis of Variance; Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial effect; Bacteria - drug effects; Boron Compounds - chemistry; Boron Compounds - pharmacology; Cattle; Composite Resins - chemistry; Dental Bonding; Dental Stress Analysis - instrumentation; Dentin - ultrastructure; Dentin bonding; Dentin-Bonding Agents - chemistry; Dentin-Bonding Agents - pharmacology; Dentistry; Methacrylates - chemistry; Methacrylates - pharmacology; Methylmethacrylate - chemistry; Methylmethacrylates - chemistry; Methylmethacrylates - pharmacology; Metronidazole - chemistry; Metronidazole - pharmacology; Polymethyl Methacrylate - chemistry; Resin Cements - chemistry; Resin Cements - pharmacology; Streptococcus - drug effects; Streptococcus mutans - drug effects; Streptococcus sanguis - drug effects; Tensile Strength; Vancomycin - chemistry; Vancomycin - pharmacology
• ISSN: 0287-4547; 1881-1361
• DOI: 10.4012/dmj.19.65

To produce a bonding system which has both high bond strength and antibacterial properties, an antibacterial agent (vancomycin: VCM or metronidazol: MN) was added to the PMMA powder of 4-META/MMA-TBB resin (CB). The influence of the addition of an antibacterial agent on tensile bond strength to dentin and the antibacterial effect were investigated in this study. Forty-seven freshly extracted bovine first or second incisors were used to measure the tensile bond strength to dentin. The bond strengths to bovine dentin were not significantly decreased by addition of VCM (1%, 2%, 5%), or MN (1%) to CB (p<0.05). The antibacterial effect of CB containing antibacterial agent on six strains of bacteria was investigated by the agar plate diffusion method, analyzing the appearance of the inhibition zone around a resin disk following anaerobic culturing. The resin disks containing VCM showed antibacterial effects on all of the strains examined; the widths of the inhibition zones were 4-15mm. The resin disks containing MN showed antibacterial effects on three strains; the widths of the inhibition zones were 0-4mm. It was thus possible to produce a bonding system with both antibacterial effect and high tensile bond strength by addition of VCM to PMMA powder.