Cytogenetics and cancer

Techniques based on fluorescence in situ hybridization (FISH) have bridged the gap between molecular genetics and conventional cytogenetics. Since its introduction in the late 1980s, advanced FISH-based methods have greatly enhanced the cytogenetic analysis of hematopoietic and solid tumors and are...

Full description

Saved in:

Bibliographic Details
Published in:	Current opinion in oncology Vol. 12; no. 1; pp. 62 - 67
Main Authors:	Patel, Ankita S, Hawkins, Anita L, Griffin, Constance A
Format:	Journal Article
Language:	English
Published:	United States Lippincott Williams & Wilkins, Inc 01-01-2000
Subjects:	Chromosome Aberrations - diagnosis Chromosome Disorders Cytogenetics - trends Humans In Situ Hybridization, Fluorescence - methods Karyotyping - methods Neoplasms - genetics
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Techniques based on fluorescence in situ hybridization (FISH) have bridged the gap between molecular genetics and conventional cytogenetics. Since its introduction in the late 1980s, advanced FISH-based methods have greatly enhanced the cytogenetic analysis of hematopoietic and solid tumors and are rapidly gaining ground in clinical cytogenetic diagnostics. As interest in FISH technologies has grown, it has inspired an era of new FISH-based technologies such as multiplex FISH, spectral karyotyping, and comparative genomic hybridization. In this review, the focus is on the impact of these technologies in the field of cancer genetics.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1040-8746 1531-703X
DOI:	10.1097/00001622-200001000-00011