Separation of some platinum(II) complexes by ionic strength gradient on a solvent-generated ion-exchange sorbent

The compatibility of ionic strength gradient with solvent-generated ion-exchange chromatography on an octadecylsilica sorbent was proven for a mobile phase containing octanesulphonate. Only a slight baseline shift was observed during the gradient of the phosphate buffer, even at 210 nm. An equilibra...

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Bibliographic Details
Published in:	Journal of chromatography Vol. 586; no. 2; p. 291
Main Authors:	Macka, M, Borák, J, Kiss, F
Format:	Journal Article
Language:	English
Published:	Netherlands 22-11-1991
Subjects:	Carboplatin - analysis Chromatography, Ion Exchange - methods Cisplatin - analysis Organoplatinum Compounds - analysis Osmolar Concentration Reproducibility of Results
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Summary:	The compatibility of ionic strength gradient with solvent-generated ion-exchange chromatography on an octadecylsilica sorbent was proven for a mobile phase containing octanesulphonate. Only a slight baseline shift was observed during the gradient of the phosphate buffer, even at 210 nm. An equilibration time of 3 min between the runs was sufficient to obtain retention times with a reproducibility better than 1%. The compounds separated were cisplatin, carboplatin and related neutral and cationic platinum(II) complexes, including transplatin and the aquation products of cisplatin.
DOI:	10.1016/0021-9673(91)85135-3