The multifunctional RNase XRN2

Different classes of RNA function in various cellular processes, and their biogenesis and turnover involve diverse RNases for processing and degradation. XRN2 is a 5'→3' exoribonuclease that is evolutionarily conserved in eukaryotes. It is predominantly localized in the nucleus and recogni...

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Bibliographic Details
Published in:	Biochemical Society transactions Vol. 41; no. 4; p. 825
Main Authors:	Miki, Takashi S, Großhans, Helge
Format:	Journal Article
Language:	English
Published:	England 01-08-2013
Subjects:	Animals Exoribonucleases - metabolism Humans Quality Control RNA - metabolism
Online Access:	Get more information
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Summary:	Different classes of RNA function in various cellular processes, and their biogenesis and turnover involve diverse RNases for processing and degradation. XRN2 is a 5'→3' exoribonuclease that is evolutionarily conserved in eukaryotes. It is predominantly localized in the nucleus and recognizes single-stranded RNA with a 5'-terminal monophosphate to degrade it processively to mononucleotides. In the present paper, we review functions of XRN2 and its cofactors in maturation, surveillance and activity control of several classes of RNA such as pre-mRNA (precursor mRNA), rRNA and snoRNA (small nucleolar RNA).
ISSN:	1470-8752
DOI:	10.1042/bst20130001