Synthesis and Antiproliferative Activity of Daunorubicin Conjugates with Sesquiterpene Lactones

Synthesis and Antiproliferative Activity of Daunorubicin Conjugates with Sesquiterpene Lactones

The anthracycline antibiotic daunorubicin was modified by alantolactone, isoalantolactone, and alloahntolactone, i.e., sesquitapene lactones from Inula helenium L. The antiproliferative properties of the synthesized conjugates were studied using tumor and normal cell lines. It was found that the con...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal Vol. 52; no. 4; pp. 308 - 311
Main Authors: Anikina, L. V., Semakov, A. V., Afanas’eva, S. V., Pukhov, S. A., Klochkov, S. G.
Format: Journal Article
Language:English
Published: New York Springer US 01-07-2018
Springer
Subjects:
Antibiotics
Antineoplastic agents
Daunorubicin
Lactones
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
sesquiterpene lactones
MTT assay
cytotoxicity
daunorubicin
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Summary:The anthracycline antibiotic daunorubicin was modified by alantolactone, isoalantolactone, and alloahntolactone, i.e., sesquitapene lactones from Inula helenium L. The antiproliferative properties of the synthesized conjugates were studied using tumor and normal cell lines. It was found that the conjugate of daunorubicin with alantolactone possessed more pronounced antiproliferative properties than daunorubicin for several tumor cell cultures without increasing the toxicity for normal cells.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-018-1812-7