Prominent Inhibitory Effect of 2-Hydroxybutyl-β-cyclodextrin on Solution-mediated Polymorphic Transition of Chlorpropamide
The effects of cyclodextrins on crystallization of chlorpropamide from aqueous solutions were investigated. Parent α-, β-, and γ-cyclodextrins and 2-hydroxypropyl-α-, and -β-cyclodextrins and glucose did not change the crystallization of the drug, providing the stable Form A crystal. On the other ha...
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| Published in: | Chemistry letters Vol. 37; no. 8; pp. 816 - 817 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
The Chemical Society of Japan
05-08-2008
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| Online Access: | Get full text |
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| Summary: | The effects of cyclodextrins on crystallization of chlorpropamide from aqueous solutions were investigated. Parent α-, β-, and γ-cyclodextrins and 2-hydroxypropyl-α-, and -β-cyclodextrins and glucose did not change the crystallization of the drug, providing the stable Form A crystal. On the other hand, 2-hydroxybutyl-β-cyclodextrin inhibited the solution-mediated polymorphic transition of the drug, providing the metastable Form II at higher cyclodextrin concentrations and Form III at lower cyclodextrin concentrations. The results suggested that 2-hydoxybutyl-β-cyclodextrin is useful for preparing metastable crystals during crystallization according to the Ostwald rule. |
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| ISSN: | 0366-7022 1348-0715 |
| DOI: | 10.1246/cl.2008.816 |