Investigation of Toxic Effect and Penetration into Cells of Monodisperse Spherical Composite Particles Based on Mesoporous Silica

• Published in: Technical physics Vol. 63; no. 9; pp. 1316 - 1322
• Main Authors: Shmakov, S. V., Klimenko, V. V., Konyakhin, S. V., Eurov, D. A., Kurdyukov, D. A., Golubev, V. G.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01-09-2018; Springer; Springer Nature B.V
• Subjects: Chemisorption; Classical and Continuum Physics; Core-shell structure; Development of Process Technologies; Diagnostic Methods; Dye penetrants; Fluorescein; Fluorescence; Fluorescent dyes; Functional Materials and Structures; Investigations; Iron oxides; Organic chemistry; Particulate composites; Penetration; Physics; Physics and Astronomy; Porous materials; Silica; Silicon dioxide; Synthesis; Toxicity; Mesoporous Silica; Radachlorin; Hybrid Particle; Active Organic Components; Composite Particles
• ISSN: 1063-7842; 1090-6525
• DOI: 10.1134/S1063784218090190

Сomposite particles based on monodisperse spherical mesoporous silica particles (MSMSPs) are synthesized by noncovalent binding of organic active components (propidium iodide fluorescent dye and Radakchlorin photosensitizer) from aqueous solutions. Hybrid particles with a core–shell structure are synthesized, which are MSMSPs filled with Fe
3
O
4
and coated with mesoporous silica, the internal surface of which is modified by Fluorescein isothiocyanate (FITC) fluorescence dye by means of chemisorption. The toxicity and penetration of the obtained particles into the cells of the HeLa and K-562 cell lines were studied. The effective photodynamic action of MSMSPs containing Radachlorin in mesopores is demonstrated, which indicates the promise of using the synthesized composite particles for medical purposes.