A New Liquid-Phase Method for the Synthesis of Octreotide

A method was developed for the production of octreotide – a synthetic analog of the natural hormone somatostatin - by liquid-phase peptide synthesis using the 4 + 2 + 2 strategy. The new method is easily scalable and produces the target peptide with a yield of 56.4%.

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Bibliographic Details
Published in:	Pharmaceutical chemistry journal Vol. 47; no. 7; pp. 378 - 381
Main Authors:	Balaev, A. N., Osipov, V. N., Okhmanovich, K. A., Reshetnikov, E. V., Fedorov, and V. E.
Format:	Journal Article
Language:	English
Published:	Boston Springer US 01-10-2013 Springer
Subjects:	Drug Synthesis Methods and Manufacturing Technology Medicine Methods Organic Chemistry Pharmacology/Toxicology Pharmacy Somatotropin liquid-phase synthesis production octreotide
Online Access:	Get full text
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Description
Summary:	A method was developed for the production of octreotide – a synthetic analog of the natural hormone somatostatin - by liquid-phase peptide synthesis using the 4 + 2 + 2 strategy. The new method is easily scalable and produces the target peptide with a yield of 56.4%.
ISSN:	0091-150X 1573-9031
DOI:	10.1007/s11094-013-0963-9