Pharmacokinetics and excretion of iohexol after lumbar myelography in man

• Published in: Investigative radiology Vol. 20; no. 6; p. 632
• Main Authors: Shaw, D D, Kido, D K, Stroshane, R M, Palace, G P, Sahler, L
• Format: Journal Article
• Language: English
• Published: United States 01-09-1985
• Subjects: Adult; Aged; Back Pain - diagnostic imaging; Cauda Equina - metabolism; Contrast Media - metabolism; Female; Half-Life; Humans; Intervertebral Disc Displacement - metabolism; Iodobenzoates - metabolism; Iohexol; Kinetics; Lumbar Vertebrae - diagnostic imaging; Male; Middle Aged; Myelography; Neurilemmoma - metabolism; Peripheral Nervous System Neoplasms - metabolism; Spinal Stenosis - metabolism; Tomography, X-Ray Computed; Triiodobenzoic Acids - metabolism
• ISSN: 0020-9996
• DOI: 10.1097/00004424-198509000-00020

Pharmacokinetics and excretion of iohexol, a new nonionic water-soluble contrast medium, were determined after lumbar myelography. Peak plasma concentrations were obtained 2 to 6 hours after injection and ranged from 29 to 177 microgram/ml. Terminal elimination half-life was 4.0 hours, and over 90% of the dose was recovered in the urine within 24 hours. In one patient with a large lumbar cauda equina tumor, absorption and excretion were delayed; but eventually 99% was recovered indicating a large capacity for reabsorption via the lumbar subarachnoid space. One mild headache of 5 minutes' duration was reported in a 73-year-old woman. No significant changes in vital signs, neurologic examinations, or serum chemistries were observed.