Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases

Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber number and size. The myostatin pathway is conserved and regulates muscle mass in a number of animal species ranging from fish to humans. Inhibition of myostatin using a variety of therapeutic...

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Bibliographic Details
Published in:	Current opinion in pharmacology Vol. 5; no. 3; pp. 328 - 332
Main Authors:	Tobin, James F, Celeste, Anthony J
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-06-2005
Subjects:	Animals Humans Muscular Diseases - physiopathology Muscular Diseases - therapy Myostatin Signal Transduction - drug effects Signal Transduction - physiology Transforming Growth Factor beta - adverse effects Transforming Growth Factor beta - antagonists & inhibitors Transforming Growth Factor beta - physiology
Online Access:	Get full text
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Summary:	Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber number and size. The myostatin pathway is conserved and regulates muscle mass in a number of animal species ranging from fish to humans. Inhibition of myostatin using a variety of therapeutic approaches can increase muscle mass in a number of animal models of human disease, including muscular dystrophy.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2005.01.011