Copper-Mediated Deuterotrifluoromethylation of α-Diazo Esters

A copper-mediated deuterotrifluoromethylation of α-diazo esters under the promotion of deuterium oxide （D20） has been developed for the synthesis of deuterium-labeled trifluoromethyl compounds. This deuterotrifluoromethyl- ation reaction is of broad scope and can afford the deuterated products with...

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Bibliographic Details
Published in:	Chinese journal of chemistry Vol. 34; no. 5; pp. 469 - 472
Main Authors:	Hu, Mingyou, Xie, Qiqiang, Li, Xinjin, Ni, Chuanfa, Hu, Jinbo
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 01-05-2016 WILEY‐VCH Verlag
Subjects:	copper deuterium diazo compounds trifluoromethylation 三氟甲基化介导反应实验证据标记化合物氘同位素重氮酯铜
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Summary:	A copper-mediated deuterotrifluoromethylation of α-diazo esters under the promotion of deuterium oxide （D20） has been developed for the synthesis of deuterium-labeled trifluoromethyl compounds. This deuterotrifluoromethyl- ation reaction is of broad scope and can afford the deuterated products with higher than 99% isotopic purity. More- over, the results of this investigation also provide some experimental evidences to support our previously proposed trifluoromethylation mechanism.
Bibliography:	31-1547/O6 copper, trifluoromethylation, deuterium, diazo compounds A copper-mediated deuterotrifluoromethylation of α-diazo esters under the promotion of deuterium oxide （D20） has been developed for the synthesis of deuterium-labeled trifluoromethyl compounds. This deuterotrifluoromethyl- ation reaction is of broad scope and can afford the deuterated products with higher than 99% isotopic purity. More- over, the results of this investigation also provide some experimental evidences to support our previously proposed trifluoromethylation mechanism. the Chinese Academy of Sciences ark:/67375/WNG-S47TKVWZ-3 the National Natural Science Foundation of China - No. 21372246, 21421002 and 21472221 the National Basic Research Program of China - No. 2015CB931900 and 2012CB821600 ArticleID:CJOC201600004 Shanghai Science and Technology program - No. 15XD1504400 MSD China R&D Postdoc Fellowship istex:D9FE9F1EA8B5D79EA077F94E52457F1D941F4033
ISSN:	1001-604X 1614-7065
DOI:	10.1002/cjoc.201600004