Palladium‐Catalyzed Thiocarbonylation of Benzyl Chlorides with Sulfonyl Chlorides for the Synthesis of Arylacetyl Thioesters

Palladium‐Catalyzed Thiocarbonylation of Benzyl Chlorides with Sulfonyl Chlorides for the Synthesis of Arylacetyl Thioesters

A convenient procedure for the synthesis of thioesters has been developed via a palladium‐catalyzed thiocarbonylation of benzyl chlorides with sulfonyl chlorides. Various arylacetyl thioesters were produced in good yields by using sulfonyl chlorides as an odorless sulfur source. Furthermore, W(CO)6...

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Bibliographic Details
Published in:Advanced synthesis & catalysis Vol. 363; no. 10; pp. 2541 - 2545
Main Authors: Wang, Wei, Qi, Xinxin, Wu, Xiao‐Feng
Format: Journal Article
Language:English
Published: Heidelberg Wiley Subscription Services, Inc 18-05-2021
Subjects:
Benzyl chloride
Carbon monoxide
Carbonylation
Chlorides
Palladium
palladium catalyst
Reducing agents
Sulfonyl Chloride
Thioester
Thioesters
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Summary:A convenient procedure for the synthesis of thioesters has been developed via a palladium‐catalyzed thiocarbonylation of benzyl chlorides with sulfonyl chlorides. Various arylacetyl thioesters were produced in good yields by using sulfonyl chlorides as an odorless sulfur source. Furthermore, W(CO)6 exhibited dual roles as both a solid CO surrogate and reductant here.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202100112