Click Chemistry: Evolving on the Fringe

Click Chemistry: Evolving on the Fringe

Summary The article herein briefly introduces the story of the birth of click chemistry and its evolution after that. A new angle to interpret click reactions was proposed using the “reactivity‐availability‐functionality” trilogy. CuAAC (Copper‐catalyzed azide‐alkyne cycloaddition), the most popular...

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Bibliographic Details
Published in:Chinese journal of chemistry Vol. 38; no. 4; pp. 414 - 419
Main Authors: Xu, Long, Dong, Jiajia
Format: Journal Article
Language:English
Published: Weinheim WILEY‐VCH Verlag GmbH & Co. KGaA 01-04-2020
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Subjects:
Alkynes
Bioconjugation
Chemical reactions
Chemical synthesis
Chemistry
Click chemistry
CuAAC
Cycloaddition
Diazotransfer
Evolution
SuFEx
Sulfur
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Summary:Summary The article herein briefly introduces the story of the birth of click chemistry and its evolution after that. A new angle to interpret click reactions was proposed using the “reactivity‐availability‐functionality” trilogy. CuAAC (Copper‐catalyzed azide‐alkyne cycloaddition), the most popular click reaction by far, was revisited along with the thiol‐ene, metal‐free AAC, SuFEx (Sulfur(VI) fluoride exchange) and the lately discovered diazotransfer process. By encountering more and more near‐perfect reactions, click chemistry is evolving and expanding on the fringe of the chemistry and different scientific disciplines, destination unknown.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201900421