Potential Biomarkers of impulsivity in mild traumatic brain injury: A pilot study

• Published in: Behavioural brain research Vol. 449; p. 114457
• Main Authors: Cardoso, Maíra Glória de Freitas, de Barros, João Luís Vieira Monteiro, de Queiroz, Rafael Alves Bonfim, Rocha, Natalia Pessoa, Silver, Carlisa, da Silva, Agnes Stéphanie, da Silva, Ewelin Wasner Machado, Roque, Isadora Gonçalves, Carvalho, Júlia de Lima, dos Santos, Laura Ferreira, Cota, Letícia Bitencourt, Lemos, Lucas Miranda, Miranda, Mariana Figueiredo, Miranda, Millena Figueiredo, Vianna, Pedro Parenti, Oliveira, Rafael Arantes, de Oliveira Furlam, Tiago, Soares, Túlio Safar Sarquis, Pedroso, Vinicius Sousa Pietra, Faleiro, Rodrigo Moreira, Vieira, Érica Leandro Marciano, Teixeira, Antônio Lúcio, de Souza, Leonardo Cruz, de Miranda, Aline Silva
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 09-07-2023
• Subjects: Biomarkers; Blood biomarkers; Brain Concussion - complications; Executive Function; Humans; Impulsive Behavior - physiology; Impulsivity; Inhibitory control; Machine Learning; mTBI; Pilot Projects; NGAL; APP; Inhibitory control; TNF-alpha; sICAM-1, Catepsin D [Cathepsin D]; NCAM; MDC; MPO; GCSF; Blood biomarkers; Neuropilin-1; GM-CSF; S100-B; PAI-1; IFN-alpha2 [IFN-alpha 2]; MIP-1alpha; MIP-1beta; NSE; IL-12p40; IL-4; IL-15; IL-5; IL-2; IL-13; IL-3; MIF; VEGF-A; IL-9; IL-10; IL-6; IL-7; sCD40L; MMP-1; mTBI; MMP-9; MCP-1; GRO; sVCAM-1; IL-1beta; NRG1-beta1 [NRG1-beta 1]; Machine Learning; IL-1aplha; IL-8/CXCL8; PDGF-AA; VEGF-R2/KDR; Impulsivity; IL-17A; EGF; BDNF; UCH-L1/ PARK-5; TGF-alpha; RAGE; FGF-2; PDGF-AB/BB; IFN-gamma; TNFSF14/LIGHT; IL-12p70; MCP-3
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/j.bbr.2023.114457

Very few studies have investigated cognition and impulsivity following mild traumatic brain injury (mTBI) in the general population. Furthermore, the neurobiological mechanisms underlying post-TBI neurobehavioral syndromes are complex and remain to be fully clarified. Herein, we took advantage of machine learning based-modeling to investigate potential biomarkers of mTBI-associated impulsivity. Twenty-one mTBI patients were assessed within one-month post-TBI and their data were compared to 19 healthy controls on measures of impulsivity (Barratt Impulsiveness Scale – BIS), executive functioning, episodic memory, self-report cognitive failures and blood biomarkers of inflammation, vascular and neuronal damage. mTBI patients were significantly more impulsive than controls in BIS total and subscales. Serum levels of sCD40L, Cathepsin D, IL-4, Neuropilin-1, IFN-α2, and Copeptin were associated with impulsivity in mTBI patients. Besides showing that mTBI are associated with impulsivity in non-military people, we unveiled different pathophysiological pathways potentially implicated in mTBI-related impulsivity.
•mTBI patients from general population display high levels of impulsivity.•mTBI-related impulsivity was successfully detected by self-report measures.•Inflammatory, vascular, and neuronal/glial mediators are associated with mTBI impulsivity.•Serum molecules might be potential biomarkers of post-mTBI impulsivity.