Associations of Physical Activity Energy Expenditure with Nutritional-Inflammatory Markers in Hemodialysis Patients

• Published in: International journal of artificial organs Vol. 40; no. 12; pp. 670 - 675
• Main Authors: Santos, Clarcson P., Silva, Luciana F., Lopes, Marcelo B., Martins, Márcia T.S., Kraychete, Angiolina C., Silva, Fernanda A., Martins, Maria T.S., Matos, Cácia M., Lopes, Gildete B., Lopes, Antonio A.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01-12-2017; Wichtig Editore s.r.l
• Subjects: Adipose tissue; Age; Anthropometry; Bioindicators; C-reactive protein; Confidence intervals; Diabetes mellitus; Dialysis; End-stage renal disease; Energy expenditure; Exercise; Health risk assessment; Hemodialysis; Inflammation; Kidney diseases; Magnetohydrodynamics; Males; Malnutrition; Markers; Nutrition; Patients; Physical activity; Proteins; Regression analysis; Regression models; Statistical analysis; Energy expenditure; Dialysis; Inflammation; Nutrition; Physical activity; Hemodialysis
• ISSN: 0391-3988; 1724-6040
• DOI: 10.5301/ijao.5000632

Background
Sedentariness, high inflammation status and malnutrition are highly prevalent in end-stage kidney disease patients on maintenance hemodialysis (MHD). This study investigated associations of weekly physical activity energy expenditure (PAEE) with clinical and anthropometric markers of nutrition and inflammation.
Methods
The analysis was performed using baseline cross-sectional data of 640 patients enrolled in the prospective cohort “The Prospective Study of the Prognosis of Patients Treated Chronically by Hemodialysis” (PROHEMO) developed in Salvador, BA, Brazil. The long version of the International Physical Activity Questionnaire was used to determine a summary measure of PAEE, the metabolic equivalent of task (MET), taking into account physical activities related to occupation, recreation, travel, sports, and housework. PAEE was the predictor variable. To assess associations of PAEE with outcomes, the sex-age-specific median MET was used. The malnutrition-inflammation score (MIS) with range of 0 to 30 (higher is worse), conicity index as indicator of abdominal adiposity and C-reactive protein (CRP) were the nutritional-inflammatory outcomes.
Results
The mean age of the patients was 48.9 ± 13.8 y, 60.3% were males, 16.7% diabetic, 88.1% nonwhite. In multivariable logistic regression models with adjustments for sociodemographic variables and comorbidities, PAEE ≤median was associated with MIS ≥6 (odds ratio [OR] = 1.57; 95% confidence interval [CI] = 1.08, 2.29), conicity index ≥1.3 (OR = 1.52, 95% CI = 1.03, 2.23) and CRP >1.30 mg/dL (OR = 1.69, 95% CI = 1.08, 2.84).
Conclusions
Greater physical activity assessed by PAEE was associated with indicators of better nutritional and inflammation status. These results indicate opportunities for improving outcomes in MHD patients by counseling and treatment intervention.