Silymarin recovers 6-hydroxydopamine-induced motor deficits in mice

Silymarin recovers 6-hydroxydopamine-induced motor deficits in mice

•Silymarin recovered 6-OHDA-induced motor impairment.•6-OHDA caused an increase in phospho-ERK1/2 levels.•Silymarin did not modify the alterations in TH and phospho-ERK1/2 in striatum.

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Bibliographic Details
Published in:Food and chemical toxicology Vol. 118; pp. 549 - 556
Main Authors: de Freitas, Catiuscia Molz, Krum, Bárbara Nunes, Chiapinotto Ceretta, Ana Paula, Schaffer, Larissa Finger, de Moraes Reis, Elizete, Schwerz, Janaína Paola, Barbosa, Caroline Pilecco, Soares, Félix Alexandre Antunes, Fachinetto, Roselei
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-08-2018
Online Access:Get full text
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Description
Summary:•Silymarin recovered 6-OHDA-induced motor impairment.•6-OHDA caused an increase in phospho-ERK1/2 levels.•Silymarin did not modify the alterations in TH and phospho-ERK1/2 in striatum.
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ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2018.05.062