Synthesis, structural characterization, fluorescence, antimicrobial, antioxidant and DNA cleavage studies of Cu(II) complexes of formyl chromone Schiff bases

• Published in: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 102; pp. 159 - 168
• Main Authors: Kavitha, P., Saritha, M., Laxma Reddy, K.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01-02-2013
• Subjects: Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antimicrobial activity; Antioxidant; Antioxidants - chemical synthesis; Antioxidants - chemistry; Antioxidants - pharmacology; Bacteria - drug effects; Bacterial Infections - drug therapy; Biphenyl Compounds - chemistry; Candida albicans - drug effects; Candidiasis - drug therapy; Chromones - chemical synthesis; Chromones - chemistry; Chromones - pharmacology; Coordination Complexes - chemical synthesis; Coordination Complexes - chemistry; Coordination Complexes - pharmacology; Copper - chemistry; Copper - pharmacology; DNA - chemistry; DNA cleavage; DNA Cleavage - drug effects; Fluorescence; Formylchromone; Humans; Picrates - chemistry; Schiff Bases - chemical synthesis; Schiff Bases - chemistry; Schiff Bases - pharmacology; Fluorescence; Formylchromone; DNA cleavage; Antimicrobial activity; Antioxidant
• ISSN: 1386-1425; 1873-3557
• DOI: 10.1016/j.saa.2012.10.037

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► Formyl chromone Schiff bases and their Cu(II) complexes have been synthesized and characterized. ► The synthesized complexes acts as potential anti oxidant agents. ► All ligands and their Cu(II) complexes exhibit good fluorescence. ► Complexes displayed an efficient DNA cleavage activity when compared with the ligands.
Cu(II) complexes have been synthesized from different Schiff bases, such as 3-((2-hydroxy phenylimino)methyl)-4H-chromen-4-one (HL1), 2-((4-oxo-4H-chromen-3-yl)methylneamino) benzoicacid (HL2), 3-((3-hydroxypyridin-2-ylimino)methyl)-4H-chromen-4-one (HL3) and 3-((2-mercaptophenylimino)methyl)-4H-chromen-4-one (HL4). The complexes were characterized by analytical, molar conductance, IR, electronic, magnetic, ESR, thermal, powder XRD and SEM studies. The analytical data reveal that metal to ligand molar ratio is 1:2 in all the complexes. Molar conductivity data indicates that all the Cu(II) complexes are neutral. On the basis of magnetic and electronic spectral data, distorted octahedral geometry is proposed for all the Cu(II) complexes. Thermal behaviour of the synthesized complexes illustrates the presence of lattice water molecules in the complexes. X-ray diffraction studies reveal that all the ligands and their Cu(II) complexes have triclinic system with different unit cell parameters. Antimicrobial, antioxidant and DNA cleavage activities indicate that metal complexes exhibited greater activity as compared with ligands.