"Inverse" synthesis of polymer bioconjugates using soluble supports

Well-defined cleavable or non-cleavable soluble polystyrene supports were prepared by atom transfer radical polymerization and utilized for the iterative synthesis of functional hexapeptides. This approach allowed rapid and efficient liquid phase synthesis of peptide-polymer conjugates.

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Bibliographic Details
Published in:	Chemical communications (Cambridge, England) Vol. 48; no. 32; p. 3887
Main Authors:	Meszynska, Anna, Badi, Nezha, Börner, Hans G, Lutz, Jean-François
Format:	Journal Article
Language:	English
Published:	England 01-01-2012
Subjects:	Amino Acid Sequence Oligopeptides - chemistry Polymerization Polymers - chemistry Polystyrenes - chemistry
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Abstract	Well-defined cleavable or non-cleavable soluble polystyrene supports were prepared by atom transfer radical polymerization and utilized for the iterative synthesis of functional hexapeptides. This approach allowed rapid and efficient liquid phase synthesis of peptide-polymer conjugates.
AbstractList	Well-defined cleavable or non-cleavable soluble polystyrene supports were prepared by atom transfer radical polymerization and utilized for the iterative synthesis of functional hexapeptides. This approach allowed rapid and efficient liquid phase synthesis of peptide-polymer conjugates.
Author	Börner, Hans G Meszynska, Anna Badi, Nezha Lutz, Jean-François
Author_xml	– sequence: 1 givenname: Anna surname: Meszynska fullname: Meszynska, Anna organization: Precision Macromolecular Chemistry Group, Institut Charles Sadron, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2, France – sequence: 2 givenname: Nezha surname: Badi fullname: Badi, Nezha – sequence: 3 givenname: Hans G surname: Börner fullname: Börner, Hans G – sequence: 4 givenname: Jean-François surname: Lutz fullname: Lutz, Jean-François
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/22410574$$D View this record in MEDLINE/PubMed
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SubjectTerms	Amino Acid Sequence Oligopeptides - chemistry Polymerization Polymers - chemistry Polystyrenes - chemistry
Title	"Inverse" synthesis of polymer bioconjugates using soluble supports
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