"Inverse" synthesis of polymer bioconjugates using soluble supports

"Inverse" synthesis of polymer bioconjugates using soluble supports

Well-defined cleavable or non-cleavable soluble polystyrene supports were prepared by atom transfer radical polymerization and utilized for the iterative synthesis of functional hexapeptides. This approach allowed rapid and efficient liquid phase synthesis of peptide-polymer conjugates.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) Vol. 48; no. 32; p. 3887
Main Authors: Meszynska, Anna, Badi, Nezha, Börner, Hans G, Lutz, Jean-François
Format: Journal Article
Language:English
Published: England 01-01-2012
Subjects:
Amino Acid Sequence
Oligopeptides - chemistry
Polymerization
Polymers - chemistry
Polystyrenes - chemistry
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Description
Summary:Well-defined cleavable or non-cleavable soluble polystyrene supports were prepared by atom transfer radical polymerization and utilized for the iterative synthesis of functional hexapeptides. This approach allowed rapid and efficient liquid phase synthesis of peptide-polymer conjugates.
ISSN:1364-548X
DOI:10.1039/c2cc30233k