Rice bran extract mitigates depressive-like behavior in dextran sulfate sodium-induced colitis: Involvement of the gut-brain axis and Sirt1 signaling pathway

• Published in: Food and chemical toxicology Vol. 184; p. 114386
• Main Authors: Shendy, Hagar M., Mohamed, Sarah S., Abd El-Haleim, Enas A., Galal, Omneya, Wadie, Walaa, Helal, Amr, Khayyal, Mohamed T.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-02-2024
• Subjects: Animals; Brain-Gut Axis; Colitis; Colitis - chemically induced; Colitis - drug therapy; Colitis - metabolism; Colon - metabolism; Depression; Dextran Sulfate - toxicity; Disease Models, Animal; DSS; Gut-brain axis; Humans; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2 - metabolism; Oryza - metabolism; Rats; Rats, Wistar; Rice bran; Signal Transduction; Sirt1; Sirtuin 1 - metabolism; Sodium - chemistry; Tight junction; DSS; Gut-brain axis; Depression; Tight junction; Sirt1; Colitis; Rice bran
• ISSN: 0278-6915; 1873-6351
• DOI: 10.1016/j.fct.2023.114386

Inflammatory bowel disease (IBD) patients frequently suffer from depressive disorders as well. The present study was carried out to explore whether treatment with a standardized rice bran extract (RBE) could affect depression-like behavior in rats with dextran sulfate sodium (DSS)-induced colitis. Male Wistar rats were treated with RBE (100 mg/kg/day; p.o.) for 2 weeks. During the second week, colitis was induced by feeding the rats with 5 % (w/v) DSS in drinking water. RBE protected against DSS-induced body weight loss as well as against the macro- and microscopic inflammatory changes of the colon. Additionally, RBE mitigated DSS-induced dysregulation in blood–brain barrier tight junctional proteins, preserved the hippocampal histopathological architecture and improved the animal behavior in the forced swimming test. This was associated with modulation of hippocampal oxidative stress marker; GSH as well as hippocampal pro-inflammatory mediators; NF-ĸB and IL-1β. Treatment with RBE also led to a profound increase in the hippocampal levels of Sirt1, PGC-1α, Nrf2, and HO-1, which were drastically dropped by DSS. In conclusion, the study revealed the protective effect of RBE against DSS-induced depressive-like behavior through modulation of different parameters along the gut-brain axis and up-regulated the Sirt1/PGC-1α/Nrf2/HO-1 signaling pathway.
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•Rice bran extract (RBE) mitigates DSS-induced depressive-like behavior.•RBE prevented DSS-induced disruption of blood-brain barrier.•RBE mitigates DSS-induced neuronal oxidative stress and inflammation.•RBE modulates different parameters along the gut-brain axis.•RBE up-regulates hippocampal Sirt1/PGC-1α/Nrf2/HO-1 signaling pathway.