Pathogenesis of necrotising enterocolitis: The impact of the altered gut microbiota and antibiotic exposure in preterm infants

• Published in: Acta Paediatrica Vol. 110; no. 2; pp. 433 - 440
• Main Authors: Raba, Ali Ahmed, O'Sullivan, Anne, Miletin, Jan
• Format: Journal Article
• Language: English
• Published: Norway Wiley Subscription Services, Inc 01-02-2021
• Subjects: Anti-Bacterial Agents - adverse effects; Antibiotics; Baby foods; Biodiversity; Cancer therapies; Enterocolitis; Enterocolitis, Necrotizing - chemically induced; Gastrointestinal diseases; Gastrointestinal Microbiome; Humans; Infant; Infant, Newborn; Infant, Premature; Infants; Inflammatory bowel disease; Intensive Care Units, Neonatal; Intestinal microflora; Intestine; Microbiota; Morbidity; Necrosis; necrotising enterocolitis; Neonates; Newborn babies; Pathogenesis; Premature babies; preterm infants; Risk factors; microbiota; necrotising enterocolitis; preterm infants; antibiotics
• ISSN: 0803-5253; 1651-2227
• DOI: 10.1111/apa.15559

Necrotising enterocolitis (NEC) is a devastating condition with high morbidity and mortality seen predominately in preterm infants. Multiple factors are associated with the pathogenesis of NEC. The widespread use of antibiotics in the neonatal intensive care unit might play a role in the pathogenesis of NEC in preterm infants. This review provides a summary on the intestinal microbiota in preterm infants with a focus on how antibiotic exposure may reduce the biodiversity of the intestinal microbiota and may predispose preterm infants to NEC.
Conclusion
Prolonged antibiotic therapy has been suggested as a risk factor for the development of NEC in preterm infants.