Pharmacokinetics and safety of ticagrelor in infants and toddlers with sickle cell disease aged <24 months

• Published in: Pediatric blood & cancer Vol. 68; no. 5; pp. e28977 - n/a
• Main Authors: Duniva Inusa, Baba Psalm, Inati, Adlette, Maes, Philip, Githanga, Jessie, Ogutu, Bernhards, Abboud, Miguel R., Miano, Maurizio, Cela, Elena, Nduba, Videlis, Niazi, Mohammad, Åstrand, Magnus, Persson, Kevin, Berggren, Anders, Carlson, Glenn
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01-05-2021
• Subjects: Children; Hematology; Infants; Occlusion; Oncology; paediatric; Palatability; Pediatrics; pharmacokinetic; Pharmacokinetics; Sickle cell disease; ticagrelor; ticagrelor; pharmacokinetic; paediatric; sickle cell disease
• ISSN: 1545-5009; 1545-5017
• DOI: 10.1002/pbc.28977

Inhibition of platelet activation may reduce vaso‐occlusion rates in patients with sickle cell disease (SCD). In the HESTIA4 (NCT03492931) study, 21 children with SCD received a single oral dose of the antiplatelet agent ticagrelor (0.1 mg/kg <6 months; 0.2 mg/kg ≥6 to <24 months). All patients had measurable ticagrelor plasma concentrations. Ticagrelor and active metabolite (AR‐C124910XX) exposure were comparable across all groups (<6 months, ≥6 to <12 months and ≥12 to <24 months). Ticagrelor was well tolerated. Palatability was generally acceptable. These data will be used to enable dose selection for further investigations of ticagrelor efficacy and safety in children with SCD.