An in-vivo-in-vitro correlation for the bioavailability of frusemide tablets

The dissolution behaviour of four commercial and two experimental formulations of frusemide tablets has been investigated using the USP rotating basket apparatus and pH 5.0 buffer at 37 degrees C as the test medium. There is a linear relationship between the percentage dissolution in 30 min and the...

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Bibliographic Details
Published in:	Journal of pharmacy and pharmacology Vol. 36; no. 8; p. 536
Main Authors:	Kingsford, M, Eggers, N J, Soteros, G, Maling, T J, Shirkey, R J
Format:	Journal Article
Language:	English
Published:	England 01-08-1984
Subjects:	Biological Availability Furosemide - administration & dosage Furosemide - metabolism Humans Solubility Tablets Time Factors
Online Access:	Get more information
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Summary:	The dissolution behaviour of four commercial and two experimental formulations of frusemide tablets has been investigated using the USP rotating basket apparatus and pH 5.0 buffer at 37 degrees C as the test medium. There is a linear relationship between the percentage dissolution in 30 min and the bioavailability relative to an oral solution of frusemide over the bioavailability range 76-97%. Predicted bioavailabilities differed by no more than 2% from the measured values.
ISSN:	0022-3573
DOI:	10.1111/j.2042-7158.1984.tb04446.x