The management and course of eosinophilic oesophagitis in Israeli children

• Published in: Acta Paediatrica Vol. 110; no. 5; pp. 1653 - 1657
• Main Authors: Rosen, Irit, Mahamed, Aos, Garah, Jamal, Magen‐Rimon, Ramit, Shaoul, Ron
• Format: Journal Article
• Language: English
• Published: Norway Wiley Subscription Services, Inc 01-05-2021
• Subjects: Budesonide; Children; Diet; Endoscopy; eosinophilic oesophagitis; Esophageal diseases; Esophagitis; Esophagus; Gastroenterology; Leukocytes (eosinophilic); Medical records; paediatric; pathology; Patients; Proton pump inhibitors; Steroid hormones; treatment; treatment; endoscopy; pathology; eosinophilic oesophagitis; paediatric
• ISSN: 0803-5253; 1651-2227
• DOI: 10.1111/apa.15746

Aim
Eosinophilic oesophagitis (EoE) is a chronic inflammatory oesophageal disease, which has become more recognised in the past decade. We wanted to characterise our patients and review their course of disease and response to treatment.
Methods
We retrospectively reviewed the medical records of EoE patients from January 2010 to May 2018 in our Gastroenterology Institute. A hundred and two children were included in this study. We investigated the characteristics of patients and the response to three treatment options: proton pump inhibitors, elimination diet and topical steroids. The response to treatment was analysed according to 3 aspects: clinical, endoscopic appearance and histological features.
Results
Clinical improvement was noted in 55%, 75% and 87.5% on PPIs, diet and budesonide, respectively. Endoscopic improvement was noted in 38.4%, 51.4% and 65.4% on PPIs, diet and budesonide, respectively. Histological improvement was noted in 43.7%, 62.2% and 88.5% on PPIs, diet and budesonide, respectively.
Conclusion
Our findings suggest that Israeli paediatric EoE patients have characteristics that resemble previous reports. Although there is a correlation between symptoms, endoscopic and histological appearance, we cannot rely on patients reports alone, and therefore, repeated endoscopy and biopsies are mandated. Topical steroids seem to be the most effective treatment option.