Effect of four i.v. induction agents on T-lymphocyte proliferations to PHA in vitro

Anaesthetic agents are believed to have an adverse effect on human immunity. We have studied the effects of four i.v. induction agents, thiopentone, methohexitone, etomidate and propofol, on T-lymphocyte proliferations to phytohaemagglutinin in vitro. We found that at plasma concentrations similar t...

Full description

Saved in:

Bibliographic Details
Published in:	British journal of anaesthesia : BJA Vol. 73; no. 3; p. 315
Main Authors:	Devlin, E G, Clarke, R S, Mirakhur, R K, McNeill, T A
Format:	Journal Article
Language:	English
Published:	England 01-09-1994
Subjects:	Anesthetics, Intravenous - pharmacology Cell Division - drug effects Cells, Cultured Depression, Chemical Dose-Response Relationship, Drug Etomidate - pharmacology Female Humans Immune Tolerance - drug effects Male Methohexital - pharmacology Phytohemagglutinins - immunology Propofol - pharmacology T-Lymphocytes - drug effects T-Lymphocytes - immunology Thiopental - pharmacology
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Anaesthetic agents are believed to have an adverse effect on human immunity. We have studied the effects of four i.v. induction agents, thiopentone, methohexitone, etomidate and propofol, on T-lymphocyte proliferations to phytohaemagglutinin in vitro. We found that at plasma concentrations similar to those obtained after induction doses, all drugs, with the exception of propofol, caused depression of T-lymphocyte function.
ISSN:	0007-0912
DOI:	10.1093/bja/73.3.315