CircRNA fibroblast growth factor receptor 3 promotes tumor progression in non‐small cell lung cancer by regulating Galectin‐1‐AKT/ERK1/2 signaling

• Published in: Journal of cellular physiology Vol. 234; no. 7; pp. 11256 - 11264
• Main Authors: Qiu, Bai‐Quan, Zhang, Peng‐Fei, Xiong, Dian, Xu, Jian‐Jun, Long, Xiang, Zhu, Shu‐Qiang, Ye, Xu‐Dong, Wu, Yin, Pei, Xu, Zhang, Xue‐Mei, Wu, Yong‐Bing
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01-07-2019
• Subjects: A549 Cells; AKT protein; Biomarkers, Tumor - genetics; Cancer; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; Cell Line, Tumor; Cell Proliferation - genetics; circRNA FGFR3 (circFGFR3); Circular RNA; circular RNA (circRNA); Epithelial-Mesenchymal Transition - genetics; Extracellular signal-regulated kinase; Female; Fibroblast growth factor receptor 3; Fibroblast growth factor receptors; Galectin 1 - metabolism; Gene expression; Gene Expression Regulation, Neoplastic; Growth factors; Humans; invasion; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Male; MAP Kinase Signaling System - physiology; micro RNA; MicroRNAs - genetics; Middle Aged; Mitogen-Activated Protein Kinase 3 - metabolism; Molecular modelling; Neoplasm Invasiveness - genetics; Non-small cell lung carcinoma; non‐small cell lung cancer (NSCLC); Polymerase chain reaction; proliferation; Proto-Oncogene Proteins c-akt - metabolism; Receptor, Fibroblast Growth Factor, Type 3 - metabolism; Ribonucleic acid; RNA; RNA Interference; RNA, Circular - genetics; RNA, Small Interfering - genetics; Signaling; Treatment Outcome; invasion; proliferation; micro RNA; circRNA FGFR3 (circFGFR3); non-small cell lung cancer (NSCLC); circular RNA (circRNA)
• ISSN: 0021-9541; 1097-4652
• DOI: 10.1002/jcp.27783

The dysregulation of circular RNA (circRNA) expression is involved in the progression of several cancers, including non‐small cell lung cancer (NSCLC). However, the role and underlying molecular mechanisms of circRNA FGFR3 (circFGFR3) in NSCLC progression remains unknown. Here, we used quantitative real‐time polymerase chain reaction to validate that circFGFR3 expression was higher in NSCLC tissues than in the paratumor tissues. Furthermore, our study indicated that the forced circFGFR3 expression promoted NSCLC cell invasion and proliferation. Mechanistically, we found that circFGFR3 promoted NSCLC cell invasion and proliferation via competitively combining with miR‐22‐3p to facilitate the galectin‐1 (Gal‐1), p‐AKT, and p‐ERK1/2 expressions. Clinically, we revealed that the high circFGFR3 expression correlates with the poor clinical outcomes in patients with NSCLC. Together, these data provide mechanistic insights into the circFGFR3‐mediated regulation of both the AKT and ERK1/2 signaling pathways by sponging miR‐22‐3p and increasing Gal‐1 expression.
The dysregulation of the circular RNA (circRNA) expression is involved in the progression of several cancers, including non‐small cell lung cancer (NSCLC). Together, these data provide mechanistic insights into circRNA FGFR3 (circFGFR3)‐mediated regulation of both the AKT and ERK1/2 signaling pathways by sponging miR‐22‐3p and increasing Gal‐1 expression.