Association between GOLGB1 tag‐polymorphisms and nonsyndromic cleft palate only in the Brazilian population

• Published in: Annals of human genetics Vol. 82; no. 4; pp. 227 - 231
• Main Authors: Machado, Renato Assis, Martelli‐Júnior, Hercílio, Almeida Reis, Silvia Regina, Persuhn, Darlene Camati, Coletta, Ricardo D.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01-07-2018
• Subjects: Brazil; Case-Control Studies; Cleft lip/palate; Cleft Palate - genetics; Congenital defects; Genetic diversity; Genetic Predisposition to Disease; GOLGB1; Golgi Matrix Proteins - genetics; Haplotypes; Humans; nonsyndromic cleft palate only; Polymorphism; Polymorphism, Single Nucleotide; Population; Population genetics; risk factor; Risk factors; Single-nucleotide polymorphism; Brazil; single nucleotide polymorphism; nonsyndromic cleft palate only; risk factor; GOLGB1
• ISSN: 0003-4800; 1469-1809
• DOI: 10.1111/ahg.12242

Nonsyndromic oral clefts are common congenital birth defects that exhibit variable prevalence around the world, often influenced by population‐dependent genetic predisposition. Few studies have been performed with nonsyndromic cleft palate only (NSCPO), limiting the knowledge of the genetic risk factors related to this type of oral cleft. Genetic variants in golgin subfamily B member 1 (GOLGB1), a gene that is essential for normal murine palatogenesis, were analyzed in this study to establish its potential association with NSCPO risk in the Brazilian population. Five tag‐single nucleotide polymorphisms (SNPs) of GOLGB1 (rs1169, rs7153, rs9968051, rs9819530, and rs6794341), which capture the majority of alleles spanning within gene, were genotyped in a case–control study with 270 patients with NSCPO and 284 unrelated healthy controls. The samples were also genotyped for 40 biallelic polymorphic markers to characterize the genetic ancestry. After adjustment for co‐variants, the GOLGB1 tag‐SNPs and the haplotypes formed by those SNPs were not significantly associated with NSCPO in this Brazilian case–control cohort. Our results suggest that common polymorphisms of GOLGB1 are not associated NSCPO susceptibility in the Brazilian population.