Surging HIV‐1 CRF07_BC epidemic among recently infected men who have sex with men in Fujian, China

• Published in: Journal of medical virology Vol. 90; no. 7; pp. 1210 - 1221
• Main Authors: Chen, Zhi‐Wei, Liu, Li, Chen, Guozhong, Cheung, Ka‐Wai, Du, Yanhua, Yao, Xu, Lu, Yuan, Chen, Liang, Lin, Xinhua, Chen, Zhiwei
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01-07-2018
• Subjects: AIDS; China; CRF01_AE; CRF07_BC; Disease transmission; Emergence; Epidemics; Fujian; Genomes; Genotypes; Genotyping; HIV; HIV‐1; Human immunodeficiency virus; Immunity; Immunization; Immunization (passive); Immunoassays; Infections; MSM; Phylogenetics; Phylogeny; Recombination; Sexual transmission; Sexually transmitted diseases; STD; Strains (organisms); Virology; Youth; China; HIV-1; CRF01_AE; China; MSM; AIDS; CRF07_BC; Fujian
• ISSN: 0146-6615; 1096-9071
• DOI: 10.1002/jmv.25072

A rapidly increasing number of HIV‐1 infections have been identified among men who have sex with men (MSM) in Fujian province of China since 2010. We aimed to investigate the causative factors underlying this surging epidemic. Using immunoassays for HIV‐1 diagnosis and phylogenetic analysis for viral genotyping, we found that the number of MSM infections doubled from 171 in 2011 to 340 in 2013 with a significantly increased prevalent rate from 4.1% to 5.2%. Majority of these increased infections took place in Fuzhou, Xiamen, and Quanzhou, three large cities in Fujian, mainly among youth, unemployed, business, and well‐educated MSMs. Phylogenetic analysis revealed three major HIV‐1 genotypes including CRF01_AE, CRF07_BC, and B/B’ yet the surging MSM infections were primarily associated with the rapid sexual spread of CRF07_BC in addition to CRF01_AE. In particular, there was a significant proportional expansion of CRF07_BC infections among recently infected MSMs from 19% in 2012 to 41.9% in 2013. This increase was accompanied by emergence of complex patterns of viral recombination including multiple hybrid variants derived from CRF01_AE and CRF07_BC. Full‐genome analysis indicated that CRF07_BC in Fujian was likely originated from similar strains previously found among IDUs in Yunnan province but with unique recombination break points. Our findings indicated that HIV‐1 CRF07_BC has adapted for rapid sexual transmission, resulting in the surging HIV‐1 epidemic and the emergence of new recombinant strains among MSMs in Fujian. Our findings have implications to vaccine and passive immunization trials in Fujian with emphasis on the induction of cross‐subtype protective immunity.