Oral submucous fibrosis: An update on pathophysiology of malignant transformation

Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global healt...

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Bibliographic Details
Published in:	Journal of oral pathology & medicine Vol. 46; no. 6; pp. 413 - 417
Main Authors:	Arakeri, Gururaj, Patil, Shekar Gowda, Aljabab, Abdulsalam S., Lin, Kuan‐Chou, Merkx, M. A. W., Gao, Shan, Brennan, Peter A.
Format:	Journal Article
Language:	English
Published:	Denmark Wiley Subscription Services, Inc 01-07-2017
Subjects:	Areca - adverse effects Carcinoma, Squamous Cell - pathology Cell Transformation, Neoplastic - pathology Chewing Dentistry Fibrosis Humans malignant transformation Mouth Neoplasms - pathology oral submucous fibrosis Oral Submucous Fibrosis - pathology Precancerous Conditions review squamous cell carcinoma oral submucous fibrosis malignant transformation review squamous cell carcinoma
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Summary:	Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global health. What makes it more sinister is the malignant transformation rate, which has been reported to be around 7.6% over a 17‐year period. In this concise article, we review the current trends in the pathophysiology of malignant transformation of OSMF.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0904-2512 1600-0714
DOI:	10.1111/jop.12582