Targeting ferroptosis in gastric cancer: Strategies and opportunities

• Published in: Immunological reviews Vol. 321; no. 1; pp. 228 - 245
• Main Authors: Le, Jiahan, Pan, Guangzhao, Zhang, Che, Chen, Yitao, Tiwari, Amit K., Qin, Jiang‐Jiang
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01-01-2024
• Subjects: Amino Acids; Apoptosis; Biological activity; Cancer; Cancer therapies; Cell death; Chemotherapy; Damage accumulation; Drug resistance; Ferroptosis; Gastric cancer; GPX4; Humans; inducer; inhibitor; Iron; Lipid metabolism; Lipids; metabolism; Metastases; Peroxides; reactive oxygen species; Reagents; Stomach Neoplasms - drug therapy; inducer; ferroptosis; GPX4; gastric cancer; inhibitor; reactive oxygen species; metabolism
• ISSN: 0105-2896; 1600-065X
• DOI: 10.1111/imr.13280

Summary
Ferroptosis is a novel form of programmed cell death morphologically, genetically, and biochemically distinct from other cell death pathways and characterized by the accumulation of iron‐dependent lipid peroxides and oxidative damage. It is now understood that ferroptosis plays an essential role in various biological processes, especially in the metabolism of iron, lipids, and amino acids. Gastric cancer (GC) is a prevalent malignant tumor worldwide with low early diagnosis rates and high metastasis rates, accounting for its relatively poor prognosis. Although chemotherapy is commonly used to treat GC, drug resistance often leads to poor therapeutic outcomes. In the last several years, extensive research on ferroptosis has highlighted its significant potential in GC therapy, providing a promising strategy to address drug resistance associated with standard cancer therapies. In this review, we offer an extensive summary of the key regulatory factors related to the mechanisms underlying ferroptosis. Various inducers and inhibitors specifically targeting ferroptosis are uncovered. Additionally, we explore the prospective applications and outcomes of these agents in the field of GC therapy, emphasizing their capacity to improve the outcomes of this patient population.