Feasibility of photobiomodulation therapy for the prevention of radiodermatitis: a single-institution pilot study

• Published in: Lasers in medical science Vol. 35; no. 5; pp. 1119 - 1127
• Main Authors: Park, Ji-Hye, Byun, Hyun Jeong, Lee, Jong Hee, Kim, Haeyoung, Noh, Jae Myung, Kim, Cho Rok, Oh, Dongryul
• Format: Journal Article
• Language: English
• Published: London Springer London 01-07-2020; Springer Nature B.V
• Subjects: Cancer; Clavicle; Complications; Dentistry; Feasibility studies; Head & neck cancer; Head and neck; Lasers; Light therapy; Lung cancer; Lymph nodes; Medicine; Medicine & Public Health; Metastases; Optical Devices; Optics; Original Article; Photonics; Quality of life; Quantum Optics; Radiation; Radiation therapy; Schedules; Toxicity; Prevention; Photobiomodulation therapy; Radiodermatitis; Neck
• ISSN: 0268-8921; 1435-604X
• DOI: 10.1007/s10103-019-02930-1

Acute radiodermatitis is one of the major complications when radiation therapy (RT) is delivered to the head and neck region in cases of head and neck cancers or lung cancers with supraclavicular lymph node metastasis. In these cases, high dose of RT is generally used so that acute radiodermatitis is observed in more than 90% of patients, and it negatively affects patients’ quality of life. In this pilot study, we evaluated the clinical feasibility of photobiomodulation (PBM) therapy before conducting a randomized trial based on the hypothesis that PBM therapy may reduce the severity of radiodermatitis in participants receiving 60 Gy or higher dose. Patients who were to receive 60 Gy or higher dose in the neck were included in the study. Thirty-three patients received PBM therapy three times a week during RT. The severity of radiodermatitis was evaluated by two dermatologists and a radiation oncologist using the modified Common Terminology Criteria for Adverse Events (CTCAE). Patients were followed up until a week after RT. In all patients, 90.6% of planned PBM schedule was completed. There was no significant side effect of PBM therapy. Thirteen (39%) patients showed wet desquamation (CTCAE grade 2b or higher). Only three (9%) of them showed grade 3 toxicity, which is a favorable result compared with previous studies. This pilot study showed that PBM therapy is safe and feasible in the clinic, and it might reduce the severity of radiodermatitis. A randomized trial should be warranted to prove the efficacy of PBM therapy.