Highly exfoliated functionalized MoS2 with sodium alginate-polydopamine conjugates for electrochemical sensing of cardio-selective β-blocker by voltammetric methods

• Published in: Mikrochimica acta (1966) Vol. 188; no. 3; p. 103
• Main Authors: Lee, Chung-Yi, Prasannan, Adhimoorthy, Lincy, Varghese, Vetri Selvi, Subash, Chen, Shen−Ming, Hong, Po-Da
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01-03-2021; Springer Nature B.V
• Subjects: Analytical Chemistry; Catechol; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Dopamine; Electrodes; Exfoliation; Functional groups; Microengineering; Molybdenum disulfide; Nanochemistry; Nanocomposites; Nanotechnology; Original Paper; Oxidation; Sodium alginate; Voltammetry; Electrochemical sensor; Cyclic voltammetry; Differential pulse voltammetry; Polydopamine; Functionalized MoS; Cardio-selective β-blocker; Sodium alginate
• ISSN: 0026-3672; 1436-5073
• DOI: 10.1007/s00604-021-04717-0

Molybdenum disulfide (MoS
2
) surface functionalization was performed with a catechol-containing polymer sodium alginate (SA) and dopamine (DA) through simultaneous MoS
2
exfoliation and self-polymerization of DA. The MoS
2
/SA-PDA nanocomposite was characterized using spectroscopic, microscopic, and electroanalytical techniques to evaluate its electrocatalytic performance. The electrocatalytic behavior of the MoS
2
/SA-PDA nanocomposite modified electrode for the detection of acebutolol (ACE), a cardio-selective β-blocker drug was explored  through cyclic voltammetric and differential pulse voltammetric techniques. The influence of scan rate, concentration, and pH value on the oxidation peak current of ACE was investigated  to optimize the deducting condition. The electrochemical activity of the MoS
2
/SA-PDA nanocomposite electrode was attributed to the existence of reactive functional groups being contributed from SA, PDA, and MoS
2
exhibiting a synergic effect. The MoS
2
/SA-PDA nanocomposite modified electrode exhibits admirable electrocatalytic activity with a wide linear response range (0.009 to 520 μM), low detection limit (5 nM), and high sensitivity (0.354 μA μM
−1
 cm
−2
) also in the presence of similar (potentially interfering) compounds. The fabricated MoS
2
/SA-PDA nanocomposite modified electrode can be useful for the detection of ACE in pharmaceutical analysis.
Graphical abstract