miR-548 predicts clinical prognosis and functions as a tumor promoter in gastric cancer

• Published in: Clinical and experimental medicine Vol. 23; no. 5; pp. 1633 - 1639
• Main Authors: Chen, Guoyan, Shang, Jingjuan, Li, Minhong, Zhang, Huijun, Xu, Hui
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01-09-2023; Springer Nature B.V
• Subjects: Cell migration; Cell proliferation; Gastric cancer; Hematology; Internal Medicine; Lymph nodes; Medical prognosis; Medicine; Medicine & Public Health; Metastases; Oncology; Original Article; Prognosis; Statistical analysis; Development; Biomarker; Prognosis; Gastric cancer; miR-548
• ISSN: 1591-9528; 1591-8890; 1591-9528
• DOI: 10.1007/s10238-022-00870-9

Numerous pieces of evidence have demonstrated the functional role of miR-548 in various cancers. The expression and function of miR-548 in gastric cancer were investigated in the present study. A total of 123 gastric cancer patients were included and provided paired gastric cancer tissues and matched normal tissues. RT-qPCR was used to detect the expression of miR-548. CCK8 assay was used to evaluate cell proliferation, and Transwell assay was applied to assess cell migration and invasion. The clinical significance of miR-548 was estimated by a series of statistical analyses. miR-548 was found to be upregulated in gastric cancer, which was associated with the lymph node metastasis and TNM stage of patients. Patients with relatively high miR-548 expression possessed bad survival. miR-548 was identified as a prognostic indicator of gastric cancer. miR-548 was also found to promote the proliferation, migration, and invasion of gastric cancer. Upregulated miR-548 was involved in the progression of gastric cancer and predicted the prognosis of patients. Inhibition of miR-548 might be a novel therapeutic strategy for gastric cancer.