Direct preparation of thiazoles, imidazoles, imidazopyridines and thiazolidines from alkenes

Direct preparation of thiazoles, imidazoles, imidazopyridines and thiazolidines from alkenes

A range of heterocycles, namely thiazoles, imidazoles, imidazopyridines, thiazolidines and dimethoxyindoles, have been synthesised directly from alkenes via a two-step ketoidoination/cyclisation protocol. The alkene starting materials are themselves readily accessible using many different and well-e...

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Bibliographic Details
Published in:Organic & biomolecular chemistry Vol. 10; no. 5; p. 1093
Main Authors: Donohoe, Timothy J, Kabeshov, Mikhail A, Rathi, Akshat H, Smith, Ian E D
Format: Journal Article
Language:English
Published: England 07-02-2012
Subjects:
Alkenes - chemical synthesis
Alkenes - chemistry
Cyclization
Imidazoles - chemical synthesis
Imidazoles - chemistry
Pyridines - chemical synthesis
Pyridines - chemistry
Thiazoles - chemical synthesis
Thiazoles - chemistry
Thiazolidines - chemical synthesis
Thiazolidines - chemistry
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Summary:A range of heterocycles, namely thiazoles, imidazoles, imidazopyridines, thiazolidines and dimethoxyindoles, have been synthesised directly from alkenes via a two-step ketoidoination/cyclisation protocol. The alkene starting materials are themselves readily accessible using many different and well-established approaches, and allow access to a variety of heterocycles with excellent yields and regioselectivity.
ISSN:1477-0539
DOI:10.1039/c1ob06587d