Gonadotropins regulate tyrosine hydroxylase activity in Drosophila virilis

Tyrosine hydroxylase (TH, AN 1.14.16.2) is the first and rate-limiting enzyme in the major pathway of dopamine (DA) synthesis in Drosophila. This enzyme catalyzes the conversion of tyrosine to the DA precursor dihydroxyphenylalanine (DOPA). Earlier the authors showed that DA regulates the level of g...

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Bibliographic Details
Published in:	Doklady. Biochemistry and biophysics Vol. 423; no. 1; pp. 325 - 327
Main Authors:	Karpova, E. K., Chentsova, N. A., Adonyeva, N. V., Alekseev, A. A., Shumnaya, L. V., Gruntenko, N. E., Rauschenbach, I. Yu
Format:	Journal Article
Language:	English
Published:	Dordrecht SP MAIK Nauka/Interperiodica 01-12-2008 Springer Nature B.V
Subjects:	Animals Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Dopamine - metabolism Dopamine - physiology Drosophila - enzymology Drosophila - physiology Drosophila melanogaster - enzymology Drosophila melanogaster - physiology Drosophila virilis Enzymes Female Gonadotropins - physiology Insects Juvenile Hormones - physiology Life Sciences Molecular Biology Stress, Physiological Studies Tyrosine 3-Monooxygenase - metabolism Tyrosine Hydroxylase Control Female DOKLADY Biochemistry Heat Stress Juvenile Hormone
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Summary:	Tyrosine hydroxylase (TH, AN 1.14.16.2) is the first and rate-limiting enzyme in the major pathway of dopamine (DA) synthesis in Drosophila. This enzyme catalyzes the conversion of tyrosine to the DA precursor dihydroxyphenylalanine (DOPA). Earlier the authors showed that DA regulates the level of gonadotropinsjuvenile hormone (JH) and 20-hydroxyecdysone (20E)in female D. virilis andD. melanogaster. In young females, an increase in the level of DA results in an increase in the level of 20E and JH (degradation of the latter decreases). Gonadotropins, in turn, regulate the content of DA: an increase in the titer of JH and 20E in young Drosophila females caused a drop and increase, respectively, in the level of DA. The DA content can be regulated by gonadotropins during their synthesis, degradation, or control of the pool of precursors. One of the purposes of this study was to determine whether JH and 20E regulate the level of DA, changing the activity of TH. It was found that TH is a stress-response component in D. virilis and D. melanogaster
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	1607-6729 1608-3091
DOI:	10.1134/S160767290806001X