Simple and efficient synthesis of 2,5-anhydro-d-glucitol

Simple and efficient synthesis of 2,5-anhydro-d-glucitol

The synthesis of 2,5-anhydro-d-glucitol is described via intramolecular cyclization of diepoxide using ammonium formate in MeOH by a microwave-assisted reaction. The overall yield was 32% from d-mannitol derivative involving seven steps.

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Bibliographic Details
Published in:Tetrahedron letters Vol. 54; no. 9; pp. 1087 - 1089
Main Authors: Aragão-Leoneti, Valquiria, Carvalho, Ivone
Format: Journal Article
Language:English
Published: Elsevier Ltd 27-02-2013
Subjects:
Carbohydrate synthesis
Glucitol
Microwave-assisted reaction
Microwave-assisted reaction
Carbohydrate synthesis
Glucitol
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Description
Summary:The synthesis of 2,5-anhydro-d-glucitol is described via intramolecular cyclization of diepoxide using ammonium formate in MeOH by a microwave-assisted reaction. The overall yield was 32% from d-mannitol derivative involving seven steps.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.12.062