Techniques to Relieve Pain Associated With Botulinum Injections for Palmar and Plantar Hyperhidrosis

• Published in: Dermatologic surgery Vol. 47; no. 12; pp. 1566 - 1571
• Main Authors: Nasser, Sarah, Farshchian, Mehdi, Kimyai‐Asadi, Arash, Potts, Geoffrey A.
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 01-12-2021
• Subjects: Anesthesia; Botulinum Toxins - administration & dosage; Humans; Hyperhidrosis - drug therapy; Injections - adverse effects; Pain, Procedural - etiology; Pain, Procedural - therapy
• ISSN: 1076-0512; 1524-4725
• DOI: 10.1097/DSS.0000000000003182

Palmar and plantar hyperhidrosis (HH) is a common condition characterized by excessive sweating of the palms and soles. Botulinum neurotoxin (BTX) is a very effective and safe treatment. However, the associated intense injection pain is a major limiting factor deterring patients from selecting this treatment.
The aim of this study was to review the numerous techniques used to minimize pain accompanying injections for palmoplantar HH. Additionally, the advantages and limitations of each modality will be discussed.
The authors performed a comprehensive literature search in PubMed/MEDLINE, Embase, Cochrane Central, and Google Scholar on randomized controlled trials, cohort studies, and case series on techniques to relieve pain of BTX injections for treatment of palmar and plantar HH.
Current available techniques in reducing botulinum injection with merits and drawbacks are nerve blocks, Bier blocks, cryoanalgesia, needle-free anesthesia, topical anesthetics, and vibration anesthesia.
Topical anesthesia, ice, and vibration are the safest and most convenient noninvasive available methods to relieve pain associated with botulinum injection. Nerve blocks, Bier block, and needle-free anesthesia provide better anesthesia but are limited by the need for training and equipment.