Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Titer Levels in Pregnant Individuals After Infection, Vaccination, or Both

• Published in: Obstetrics and gynecology (New York. 1953) Vol. 141; no. 6; pp. 1199 - 1202
• Main Authors: Marshall, Christina L., Kaplowitz, Elianna, Ibroci, Erona, Chung, Kyle, Gigase, Frederieke A. J., Lieber, Molly, Graziani, Mara, Ohrn, Sophie, Lynch, Jezelle, Castro, Juliana, Tubassum, Rushna, Mutawakil, Farida, Jessel, Rebecca, Molenaar, Nina, Rommel, Anna-Sophie, Sperling, Rhoda S., Howell, Elizabeth A., Feldman, Hannah, Krammer, Florian, Stadlbauer, Daniel, de Witte, Lotje D., Bergink, Veerle, Stone, Joanne, Janevic, Teresa, Dolan, Siobhan M., Lieb, Whitney
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 01-06-2023
• ISSN: 0029-7844; 1873-233X
• DOI: 10.1097/AOG.0000000000005172

We examined differences in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody responses in pregnant individuals with natural, vaccine-induced, or combined immunity. Participants had live or nonlive births between 2020 and 2022, were seropositive (SARS-CoV-2 spike protein, anti-S), and had available mRNA vaccination and infection information (n=260). We compared titer levels among three immunity profiles1) natural immunity (n=191), 2) vaccine-induced immunity (n=37), and 3) combined immunity (ie, natural and vaccine-induced immunity; n=32). We applied linear regression to compare anti-S titers between the groups, controlling for age, race and ethnicity, and time between vaccination or infection (whichever came last) and sample collection. Anti-S titers were 57.3% and 94.4% lower among those with vaccine-induced and natural immunity, respectively, compared with those with combined immunity (P<.001, P=.005).