Proteomics and Metabolomics in Pregnancy—An Overview

• Published in: Obstetrical & gynecological survey Vol. 74; no. 2; pp. 111 - 125
• Main Authors: Vora, Niraj, Kalagiri, Ram, Mallett, Lea H, Oh, Jin Ho, Wajid, Umaima, Munir, Saef, Colon, Natalie, Raju, Venkata Nakta, Beeram, Madhava R, Nasir Uddin, M
• Format: Journal Article
• Language: English
• Published: United States Copyright Wolters Kluwer Health, Inc. All rights reserved 01-02-2019
• Subjects: Female; Humans; Metabolomics - methods; Pregnancy; Pregnancy Complications - metabolism; Proteomics - methods
• ISSN: 0029-7828; 1533-9866
• DOI: 10.1097/OGX.0000000000000646

IMPORTANCEPregnancy is getting more and more complex due to increasing number of complications that may affect fetal outcomes. The introduction of newer “proteomics and metabolomics” technologies in the field of obstetrics and gynecology may allow physicians to identify possible associated etiologies that affect the mother during pregnancy and lead to associated complications affecting the offspring.
OBJECTIVEThe principal objective of this review article is to provide a comprehensive evaluation of the use of proteomics and metabolomics in complicated pregnancies. Future studies that incorporate data from multiple technologies may allow the development of an integrated biological system approach to maternal genomes, proteomes, and metabolomes in pregnancy.
EVIDENCE ACQUISITION AND RESULTSWe conducted a substantial MEDLINE, EBSCOhost, and Cochrane database search for all the relevant articles containing use of “omics” technologies in pregnancy. We identified 197 relevant articles, following standardized systematic review process along with grading systems; 69 eligible articles were identified.
CONCLUSION/RELEVANCEWe sought to provide a comprehensive review in this emerging field of “omics” in pregnancy and associated complications. This article focuses mainly on use of proteomics and metabolomics identification techniques and possible interventions for early pregnancy complications to improve neonatal outcomes.
TARGET AUDIENCEObstetricians and gynecologists, family physicians
LEARNING OBJECTIVESAfter completing this activity, the learner should be better able to describe the various complications of pregnancy and their outcomes; assess current available techniques and modalities involving proteomics and metabolomics; and evaluate and provide a comprehensive review of the use of proteomics and metabolomic techniques in various complications of pregnancy.