Early graft dysfunction and mortality rate in marginal donor liver transplantation

• Published in: Turkish journal of medical sciences Vol. 44; no. 4; pp. 709 - 711
• Main Authors: SARKUT, Pınar, GÜLCÜ, Barış, İŞÇİMEN, Remzi, KIYICI, Murat, TÜRKER, Gürkan
• Format: Journal Article
• Language: English
• Published: Turkey Turkish Journal of Medical Sciences 01-01-2014
• Subjects: Adolescent; Adult; Age Factors; Aged; Cadaver; Child; Child, Preschool; Cold Ischemia; End Stage Liver Disease - mortality; End Stage Liver Disease - surgery; Female; Graft Survival; Humans; Key words: Marginal donor, cadaveric liver transplantation, early graft dysfunction, mortality; Liver Transplantation; Male; Middle Aged; Retrospective Studies; Risk Factors; Tissue Donors; Treatment Outcome; Young Adult
• ISSN: 1303-6165; 1300-0144; 1303-6165
• DOI: 10.3906/sag-1306-123

To determine the effect of marginal donor livers on mortality and graft survival in liver transplantation (LT) recipients. Materials and methods: Donors with any 1 of following were considered marginal donors: age =>65 years, sodium level =>165 mmol/L and cold ischemia time =>12 h. Donors were classified according to the donor risk index (DRI) 1.7. The transplant recipients' model for end-stage liver disease (MELD) scores were considered low if 20. Early graft dysfunction (EGD) and mortality rate were evaluated. Results: During the study period 47 patients underwent cadaveric LT. The mean age of the donors and recipients was 45 years (range: 5¬-72 years) and 46 years (range: 4-66 years), respectively. In all, there were 15 marginal donors and 18 donors with a DRI >1.7. In total, 4 LT patients that received livers from marginal donors and 5 that received livers from donors with a DRI =>1.7 had EGD. Among the recipients of marginal livers, 5 died, versus 4 of the recipients of standard livers. There was no significant difference in EGD or mortality rate between the patients that received livers from marginal donors or those with a DRI =>1.7 and patients that received standard donor livers. Conclusion: Marginal and DRI =>1.7 donors negatively affected LT outcomes, but not significantly.