Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients

• Published in: The New England journal of medicine Vol. 388; no. 9; pp. 804 - 812
• Main Authors: Allen, Nicholas C., Martin, Andrew J., Snaidr, Victoria A., Eggins, Renee, Chong, Alvin H., Fernandéz-Peñas, Pablo, Gin, Douglas, Sidhu, Shireen, Paddon, Vanessa L., Banney, Leith A., Lim, Adrian, Upjohn, Edward, Schaider, Helmut, Ganhewa, Aparna D., Nguyen, Jennifer, McKenzie, Catriona A., Prakash, Saurabh, McLean, Catriona, Lochhead, Alistair, Ibbetson, Jan, Dettrick, Andrew, Landgren, Anthony, Allnutt, Katherine J., Allison, Clare, Davenport, Rachael B., Mumford, Blake P., Wong, Brittany, Stagg, Brendan, Tedman, Alexander, Gribbin, Hannah, Edwards, Harrison A., De Rosa, Nicholas, Stewart, Thomas, Doolan, Brent J., Kok, Yonatan, Simpson, Kate, Low, Zhi M., Kovitwanichkanont, Tom, Scolyer, Richard A., Dhillon, Haryana M., Vardy, Janette L., Chadban, Steven J., Bowen, David G., Chen, Andrew C., Damian, Diona L.
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 02-03-2023
• Subjects: Antineoplastic Agents - administration & dosage; Antineoplastic Agents - therapeutic use; Australia; Biopsy; Blood pressure; Cancer therapies; Carcinoma, Basal Cell - etiology; Carcinoma, Basal Cell - prevention & control; Carcinoma, Squamous Cell - etiology; Carcinoma, Squamous Cell - prevention & control; Chemoprevention; Clinical trials; Dermatology; DNA damage; DNA repair; Hematology; Humans; Immunocompetence; Immunocompromised Host; Keratosis; Keratosis, Actinic - etiology; Keratosis, Actinic - prevention & control; Kidney Transplantation; Kidney transplants; Liver; Medical research; Nephrology; Niacinamide - administration & dosage; Niacinamide - therapeutic use; Nicotinamide; Oncology; Oncology General; Organ Transplantation - adverse effects; Placebos; Quality of Life; Skin Cancer; Skin diseases; Skin lesions; Skin Neoplasms - etiology; Skin Neoplasms - prevention & control; Squamous cell carcinoma; Statistical analysis; Sunscreen; Surgery; Transplant Recipients; Transplantation; Transplants & implants; Ultraviolet radiation; Ultraviolet Rays - adverse effects; Australia
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa2203086

In a placebo-controlled trial involving immunosuppressed organ-transplant recipients, oral nicotinamide (500 mg twice daily) for 12 months did not lead to lower numbers of keratinocyte cancers or actinic keratoses.